Association among tenascin-C and NT-proBNP levels and arrhythmia prevalence in heart failure

Caglar Ozmen, Ali Deniz, Onur S Deveci, Caglar E Cagliyan, Aziz I Celik, İbrahim Yildiz, Pinar Ö Yildiz, Mesut Demir, Mehmet Kanadasi

Abstract


Purpose: Tenascin-C (TN-C) and amino-terminal fragment of the B-type natriuretic peptide (NT-proBNP) are the important predictors in prognosis of heart failure (HF). The aim of this study was to analyze the relationship of TN-C and NT-proBNP levels with the frequency and severity of ventricular arrhythmia.

Materials and Methods: Our study included 107 HF patients with EF < 45%. According to Holter analysis, the patients were divided into two groups as malignant arrhythmia group (n=29) with Lown Class 4a and 4b arrhythmia and benign arrhythmia group(n=78) with Lown Class 0-3b arrhythmia. The groups were compared with respect to levels of TN-C and NT-proBNP. The relationship of TN-C and NT-proBNP levels with frequency of ventricular premature beat (VPB) was also analyzed.

Findings: NT-proBNP (5042.1±1626 versus 1417.1±1711.6 pg/ml) and TN-C (1089±348.6 versus 758.5±423.9 ng/ml) levels were significantly higher in the malignant arrhythmia group than that of the benign arrhythmia group (p<0.001). A significantly strong positive correlation (r=0.741, p<0.001) was found between the NT-proBNP levels and VPB numbers of the patients, whereas a significantly weak positive correlation was detected between the TN-C levels and VPB numbers of the patients (r=0.347, p<0.001).

Conclusion: This study has shown that NT-proBNP and TN-C levels increase in the HF patients with malignant arrhythmia. In the HF patients; the frequency of ventricular arrhythmias also increases as NT-proBNP and TN-C levels increase. However, in this study, the old NT-pro BNP seems better than the TN-C.

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DOI: http://dx.doi.org/10.25011/cim.v40i6.29122

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