Effect of One Unit Blood Donation on Appetite-Related Biomarkers

Husamettin Erdamar, Muzaffer Cakmak


Purpose: It is commonly reported that blood donation (BD) leads to an increase in appetite. To investigate this claim, a questionnaire was offered to 306 people who had a history of BD at least once in their life. Following a positive outcome from the questionnaire, we further investigated the impact of BD on appetite.

Materials and Methods: The questionnaire study consists of a 5-question survey with VAS was performed on 399 volunteers. Later, 108 volunteers were enrolled in a laboratory study. Blood samples were withdrawn before and after BD. Leptin, ghrelin, neuropeptide-Y (NPY), and alpha-melanocyte stimulating hormone (α-MSH) levels were measured by ELISA kits. VAS assessment was also performed on all participants before and after BD.

Results: There was a significant decrease in the level of leptin but the levels of ghrelin, NPY and α-MSH were unchanged. A significant change in VAS value in terms of appetite was also observed.

Conclusion: The elevation of appetite after BD is predominantly psychological. Hormonal changes may contribute to the control of hypothalamic hunger and satiety centers.

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DOI: http://dx.doi.org/10.25011/cim.v39i6.27509


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